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Big Fan isn't really a comedy, as a lot of people would probably assume. It's a drama about a man who's really, really into the New York Giants (the NFL football team).
Big Fan represents the absurdity and idolatry involved in obsessive fandom of professional athletes. The main character in the movie, played by Patton Oswalt, is a huge (huge is an understatement) fan of the Giants, and specifically their quarterback (who's a fictional character in the film).
One night when the Oswalt character and his best friend are out and about having some pizza, they discover outside that the quarterback that they fawn over is outside, getting in his vehicle.
They follow him and his buddies, and eventually get themselves into a very bad situation, wherein the quarterback they've been following ends up brutally assaulting Patton Oswalt.
After this attack is when the movie really switches tones, and we see how he deals with the entire situation, being forced to reexamine the direction his life is going.
I enjoyed it, as it was very well written and acted. I'd recommend adding it to your queue, especially if you're a fan of Oswalt.